Members of GRO protein family are detected in many cancer types, and GRO-α is frequently over-expressed in many cancers, including squamous cell carcinoma,[13] colorectal cancer,[14] breast cancer,[16] prostate cancer,[17] and ovarian cancer.[20] In addition, GRO-α is involved in many biologic activities. Here, CXCL1 is linked to Familial prostate cancer.