Multivariate Cox regression analysis further demonstrated that high GRO-α expression in the cytoplasm of cancer cells (HR = 5.730, P = 0.007) or stroma (HR = 3.120, P = 0.022), T classification (HR = 2.130, P = 0.023), lymphatic metastasis (HR = 4.211, P = 0.009), and TNM classification (HR = 0.481, P = 0.031) were independent prognostic factors for overall survival (Table 3). The gene discussed is CXCL1; the disease is cancer.