The authors showed that the miR141-CXCL1-CXCR2 pathway regulates progression of NSCLC, and that decreased level of miR141 correlates with the survival of NSCLC patients with MPE, resulted in increased expression of CXCL1 and recruitment of Tregs to facilitate immune escape of the tumor. This evidence concerns the gene CXCR2 and non-small cell lung carcinoma.