To examine whether knockdown of PRC2 expression could influence the growth of NSCLC cells, we generated EZH2, SUZ12 or EED stable knockdown NCI-H1299, NCI-H23 and NCI-H460 cell lines and validated several shRNAs that effectively depleted each PRC2 component after transfection (Supplementary Figure S1). Here, EED is linked to non-small cell lung carcinoma.