TP53 and non-small cell lung carcinoma: To determine whether the results obtained from p53-null [45] NCI-H1299 cells (Figure 4C, Supplementary Figure S3) can be generalized to p53 wild-type NSCLC cells, we generated EZH2 knockdown in p53 wild-type [46] NCI-H460 NSCLC cells (Supplementary Figure S3).