Instead, CYD 6-17 represents a new class of agent that can effectively target β-catenin gene transcription via inhibiting XBP1.XBP1 is a key factor in endoplasmic reticulum (ER) stress and unfolded protein response (UPR) has been shown to play an important role in adaptive response of cancer cells to environmental stress such as chemotherapeutics [37]. This evidence concerns the gene XBP1 and cancer.