BIRC5 and leukemia: Although we observed decreased expression of β-catenin downstream target Survivin after CYD 6-17 treatment, which could partially explain the increased apoptosis and is different from previous report about the effect of Oridonin on leukemia, implying that CYD 6-17 has distinct mechanism of action from Oridonin in TCC, while the detailed association between β-catenin and apoptosis needs further investigation.