MET phosphorylation begins to return to baseline levels by eight hours, with the degree and duration of MET inhibition correlating with dose and MET phosphorylation being fully inhibited for at least eight hours at the 30 mg/kg dose in both tumor models (Figure 8A, top; Supplementary Figure S9B, C).Thus, savolitinib inhibits MET phosphorylation to a similar extent in both the H1993 parental and clone 11 tumor models in vivo, consistent with our in vitro results. The gene discussed is MET; the disease is neoplasm.