Neutrophil plays a central role in the systemic inflammatory response, and a number of studies have demonstrated a relation between the neutrophil count or neutrophil-lymphocyte ratio and the prognosis of cancer patients [22–25], one reason of the neutrophilia is the autocrine or paraneoplastic production of myeloid growth factors, Granulocyte-colony stimulating factor (G-CSF) is one of these factors which acts selectively on bone marrow granulocytic lineage cells resulting in granulopoiesis [26–28]. This evidence concerns the gene CSF3 and cancer.