ELANE and cancer: The loss of CD4+ T lymphocyte accompanied with the impaired activation of CD8+ T lymphocyte cells may cause the insufficient secretion of cytotoxin performing anti-carcinogenic function in the neoplastic microenvironments [33], what's more, Neutrophils potentiate cancer cell migration, invasion, and dissemination by secreting immunoreactive molecules such as hepatocyte growth factor (HGF) [34, 35], oncostatin M [36], b2-integrins [37] or neutrophil elastase [38].