Although other histone methylation changes have been reported in PCa, changes in H3K27 methylation are receiving more attention since EZH2, the histone methyltransferase responsible for H3K27 methylation, is overexpressed during prostate tumorigenesis and is associated with biochemical recurrence in patients with PCa [78,80,189,190,191,192,193]. The gene discussed is PRDM9; the disease is posterior cortical atrophy.