BCL2 and Miyoshi myopathy: By altering the binding of Bim to anti-apopototic proteins, dexamethasone can induce greater affinity of Bim toward Bcl-2, resulting in increased sensitivity to venetoclax.41 Similarly, venetoclax may enhance the activity of bortezomib; this has been observed in MM xenograft models and is probably related to the inhibitory effect of bortezomib on Mcl-1 activity.42, 43 Given these interactions, additional drug combinations may be discovered, and warrant further testing and clinical trials.