glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) and total antioxidant capacity (TAC) were significantly decreased in both type 1 and type 2 diabetic groups, with and without nephropathy, comparing with normal healthy individuals (7,8) and its decrement is coordinated to severity of microalbuminuria (9,10). The gene discussed is SOD1; the disease is Nephropathy.