In contrast to conventional T cells, iNKT cells express an invariant Vα14Jα18 T cell receptor (TCR) rearrangement in mice (Vα24Jα18 in humans) that allows recognition of pathogen-associated, tumor-derived, and stress-induced glycolipids presented via the major histocompatibility complex (MHC)-like molecule CD1d.2,3. Here, CD1D is linked to neoplasm.