KCNJ5 and adenoma: However, this elegant approach combining genetic engineering and cell transplantation of bovine adrenal cells in mice may be a useful tool to test the cooperation of multiple genetic alterations in the tumorigenic process (51) or when genetic alterations may be not relevant in mouse (e.g., KCNJ5 gene, see Aldosterone-Producing Adenomas: WNT Pathway, KCNJ5, and Lack of Mouse Models).