Herroon et al. took these findings further using a mouse model of diet-induced marrow adiposity and demonstrated that FABP4 along with interleukin 1β and its target gene, oxidative stress protein, heme oxygenase 1 (HMOX-1) was also upregulated in prostate cancer cells that were in direct contact with BMAs (46). This evidence concerns the gene HMOX1 and Familial prostate cancer.