Brousseau et al. (2000) found that LCAT transgenesis also had no effect on atherosclerosis in LDL receptor negative rabbits. Although it did reduce lesions in cholesterol-fed LDL receptor positive rabbits, this was dependent on an associated reduction of LDL concentration. Van Craeyveld et al. (2009) observed no significant effect of hepatocyte-directed adenoviral rabbit LCAT gene transfer on atherosclerosis in cholesterol-fed rabbits. The gene discussed is LCAT; the disease is atherosclerosis.