The present study supports the clinical view that dysfunction of SV2A is involved in the pathogenesis of epilepsy, including intractable temporal lobe epilepsy and focal cortical dysplasia epilepsy (Feng et al., 2009; Toering et al., 2009; van Vliet et al., 2009; Crèvecoeur et al., 2014). Here, SV2A is linked to epilepsy.