Because over-activation of mTOR complex 1 (mTORC1) signaling by excessive energy intake plays a crucial role in metabolic disorders17, mTOR inhibitors such as rapamycin (23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine), metformin (1,1-dimethylbiguanide hydrochloride) and resveratrol (3,4′,5-trihydroxy-trans-stilbene) are used to treat those suffering from obesity and T2D14, 18, 19. The gene discussed is MTOR; the disease is obesity due to melanocortin 4 receptor deficiency.