HIF1A and central nervous system cancer: Importantly, using human glioma lines such as G55 and LN229, we demonstrate that, in addition to (epi)genetic events, hypoxia/HIF-1α represses ephrinB2 function, which is in line with the well-studied pro-invasive role of the HIF pathway and the activation of HIF-1α in invading glioma cells17, 40.