EFNB2 and central nervous system cancer: To gain insight into the role of the EphB/ephrinB family in glioma progression, we first screened for copy number alterations of EphB/ephrinB family members by array-based comparative genomic hybridization (CGH) in a panel of 127 grade II–IV glioma patients and found the EFNB2 gene locus to be deleted at the highest frequency (Fig. 1a).