In line with an attenuation of ephrinB2 expression by promoter hypermethylation, gliomas with increased ephrinB2 CpG island methylation exhibited significantly lower ephrinB2 levels both in our glioma cohort (Fig. 1d) and in that of The Cancer Genome Atlas (TCGA, Supplementary Fig. 1a). This evidence concerns the gene EFNB2 and glioma.