EFNB2 and central nervous system cancer: EphrinB2 KO glioma cells demonstrated increased dispersal and intermingling with co-cultured astrocytes and a markedly reduced tendency to remain clustered together (Supplementary Fig. 3c,d), indicating that ephrinB2 restricts the expansion of tumour cells by compartmentalization as, for example, shown for the EphB/ephrinB system in colorectal carcinoma27.