In our study, we found a glycine substitution p.Gly619Asp in the COL4A4 gene in a Chinese Han family with FSGS, and none of the patients in our family present ESRD, consistent with similar glycine substitution mutations that have been reported in patients with mild phenotypes and no renal failure 35. The gene discussed is COL4A4; the disease is focal segmental glomerulosclerosis.