SLC22A2 and chronic kidney disease: Moreover, treatment of male and female rats with testosterone significantly stimulated the TEA accumulation by renal slices, whereas estradiol treatment caused a decrease in the TEA accumulation by slices from male but not female rats 13.The Oct2 expression was also reported to decrease by the exogenous administration of testosterone in chronic renal failure rats and Madin–Darby canine kidney cells 31, 32.