Accordingly, we identified differential expression in several genes in Idh2R140Q mouse hearts that, when dysregulated, could be implicated in cardiomyopathy, including downregulation of Hopx (Trivedi et al 2011) and Tmod4 (Zhao et al 2013) and upregulation of Six1 (Delgado-Olguin et al 2012; Wu et al 2014) and Nmrk2 (Li et al 1999; Ruggieri et al 2015). The gene discussed is TMOD4; the disease is cardiomyopathy.