SETD7 and type 2 diabetes mellitus: In addition, the methyltransferase Set7 may play a role in epigenetic regulation of NF-κB under hyperglycemic conditions, since Set7 is upregulated in monocytes from T2D and associates with fasting plasma glucose and HbA1c, as well as H3K4m1 of the NF-κB promoter region and expression of NF-κB target genes [65].