CCL2 and Hyperglycemia: In mice, it has been shown that transient hyperglycemia induces H3K4me1 and reduces H3K9 demethylation in the promoter of the NF-κB in aortic endothelial cells, which associated with increased expression of monocyte chemoattractant protein-1 (MCP-1) and vascular cell adhesion molecule 1 (VCAM-1) and persisted for at least 6 days in vitro [60, 61].