EYA4 and metastatic malignant neoplasm in the lymph nodes: Furthermore, tumors with lymph node metastases had a lower EYA4 protein level than tumors without lymph node metastases, with a median IHC score of 3.2 (range, 0.7–6.5) vs 3.6 (range, 2.0–6.6; P < 0.001; Fig. 1i).