EYA4 and intrahepatic cholangiocarcinoma: Consistently, EYA4 protein level in ICC tissues was significantly lower than that in non-tumorous tissues, with a median IHC score of 3.4 (range, 0.7–6.6) vs 5.7 (range, 3.7–7.1; P < 0.001; Fig. 1b–g).