HSPG2 and hepatocellular carcinoma: We noted that, in comparison with siRNA control, siRNA-mediated depletion of HNF1A significantly promoted hepatoma cell proliferation (ANOVA, p = 0.001, 1.4 × 10−6, 0.091, and 0.025 in Huh7, PLC/PRF/5, SK-Hep1, and SMMC-7721, respectively) (Figure 3B), as well as its migratory capacity (p = 1.2 × 10−5, 1.7 × 10−7, 3.1 × 10−9, and 5.5 × 10−8) (Figure 3C).