Our in vitro cell experiment suggested that IDH1 may act as a tumor suppressor gene in hepatocellular carcinoma in that loss-of-function of IDH1 significantly promoted hepatoma cell growth (Figure 5B) and migration (Figure 5C); whereas overexpression of wild-type IDH1 had opposite effects (Figure 5D–5E). Here, IDH1 is linked to hepatocellular carcinoma.