The results confirmed previous meta-analyses that the risk allele of rs7903146 in TCF7L233 and rs1801278 in IRS1 and rs10830963 in MTNR1B were associated with increased risk of GDM34, while there was no significant association between rs1801282 polymorphism in PPARG and GDM risk35. The gene discussed is MTNR1B; the disease is gestational diabetes.