KIT and gastrointestinal stromal tumor: The 814 Aspartic mutation was previously found in different type of tumors and it was reported to induce a constitutive activation of c-Kit.24, 25, 26 Notably, transgenic mice carrying c-KitTgD814Y mutation were monitored for more than 2 years and no tumors such as GIST, seminoma or mastocytosis were detected.