IL10 and Hepatic fibrosis: Research has demonstrated that IL-10 could reverse hepatic fibrosis by attenuating the expression of matrix metalloproteinase and collagen.17, 18 More work also showcased the ability of IL-5 to promote the progression of hepatic fibrosis by regulating IL-13 activity.19 Together, these observations support a model in which Sjp40 might modulate liver fibrosis and exert an antifibrosis effect.