More interestingly, Foxa1 and Foxa2 cooperate with AR to promote diethylnitrosamine-induced hepatocarcinogenesis in male mice.38 In the present study, we tested Foxa1 tumorigenic potential in ES-Hepa hybrid differentiation, and our data suggest participation of Foxa1 in the tumorigenic program by contributing to cancer progression. Here, AR is linked to cancer.