Since it has been reported that co-culture with CAFs induces in tumor cells downregulation of E-cadherin,21 known miR-9 direct target,17 we therefore hypothesized that the increase in tumor cell motility induced by miR-9 internalization could be explained, at least in MDA-MB-468 cell line, by modulation of this molecule. The gene discussed is CDH1; the disease is neoplasm.