Western blotting and analysis of apoptotic markers in H358 and A549, K-RasV12-mutated NSCLC lines with different sensitivity to PGA (Figure 7a), showed activation of calpain-1, caspase-9, and caspase-3 in H358 cells but not in A549 cells. This evidence concerns the gene CAPN1 and non-small cell lung carcinoma.