NF1 and hereditary disease: 2010). The NF1 gene encodes the protein neurofibromin, which is a negative regulator of the Ras oncogene and its downstream effectors, including Ras/mitogen‐activated protein kinase (MAPK). Similar to other genetic disorders related to the Ras‐MAPK pathway, NF1, belongs to a group of genetic disorders termed “Rasopathy” (Martin et al. 1990; Upadhyaya et al. 2007; Gottfried et al. 2010).