We analyzed 20 whole exome sequences from patients affected with COS and 15 other trios that were affected by schizophrenia for variants in RTN4R and LGI1. Additionally, we screened 493 unrelated individuals from SCZ patient samples covering all coding regions and splice site junctions of RTN4R and LGI1. We identified one rare coding variant in RTN4R within the COS population, a mutation previously identified in SCZ. Here, RTN4R is linked to schizophrenia.