LGI1 and psychotic disorder: 2010; Wills et al. 2012; Lovero et al. 2015). NgR1 deletion in mice results in changes in plasticity, memory formation, and social behavior (McGee et al. 2005; Karlén et al. 2009; Lazar et al. 2011). Some LGI1 variants lead to ADLTLE and antibodies directed against LGI1 in human limbic encephalitis lead to psychosis and seizures, indicating a role for LGI1 synaptic in connectivity (Kegel et al. 2013; Deakin et al. 2014).