MetS patients with very high ASCVD risk status were less likely to attain HDL-C (32 vs. 41 %; P < 0.001), LDL-C (24 vs. 43 %; P < 0.001), non HDL-C (32 vs. 51 %; P < 0.001) and Apo B (33 vs. 40 %; P = 0.001) lipid targets when compared to those with high ASCVD risk status. The gene discussed is APOB; the disease is metabolic syndrome.