In MetS patients with very high ASCVD risk status (Fig. 3), females were less likely to attain HDL-C (27 vs. 36 %; P < 0.001), LDL-C (19 vs. 27 %; P < 0.001) and Apo B (30 vs. 35 %; P = 0.009) lipid targets when compared to males. The gene discussed is APOB; the disease is atherosclerosis.