EGFR and phenylketonuria: The major diseases associated with the predicted sequences are classified into 18 groups (Table 3), few of the most enriched groups based on Z-score are abnormal metabolism in phenylketonuria (0.33), defects in vitamin and cofactor metabolism (0.29), signaling by EGFR in cancer (0.26), disease associated with visual transduction (0.26), signaling in FGFR (0.25) etc. Surprisingly, Amyloidosis is not enriched in disease association section in this dataset and it may be since our dataset contains only reviewed entries from human proteome.