In addition, our results show higher frequency of both Tc17 cells and triple producer CD8+ T cells (IFN-γ+ TNF-α+ IL-17+ CD8+ T cells) cells, for the first time, in relapse phase of RRMS which amplify the idea that Il-17 as one of the key player in MS pathogenesis. This evidence concerns the gene CD8A and myeloid sarcoma.