Gem/212Pb-trastuzumab increased the expression of NOXA, PUMA, and P53AIP1, compared to Gem only treated tumor (Gem/212Pb-trastuzumab vs. Gem, NOXA and PUMA, p < 0.05; P53AIP1, p < 0.01). The gene discussed is TP53AIP1; the disease is neoplasm.