INS and obesity due to melanocortin 4 receptor deficiency: In particular, the adipose specific gene clusters were most enriched for lipid biosynthetic process (FDR ≤ 2.8 × 10−4), lipid metabolism (FDR ≤ 1.7 × 10−2), and insulin signaling pathway (FDR ≤ 0.046); Interestingly, artery specific functions also appeared in adipose enriched terms; it has been shown that angiogenesis and vascular functions modulate obesity, adipose metabolism, and insulin sensitivity [85].