While PM-induced depletion of several cell types may be independently important for anti-cryptosporidial defenses, CD11c+CD103+ cells that co-express the CXCR3 receptor were recently shown to be more consequential for early Cryptosporidium clearance in primary infection in neonatal mice than loss of either NK cells or T-cells [43]. The gene discussed is ITGAX; the disease is infection.