There was an enhancement of E cadherin expression and reduction in the level of N-cadherin MMP 9 and snail1 upon miR-203 transfection in HNGC2 and U87 cell line (Fig 9B). Moreover, introduction of mi-203 plus GAS41 lead to restoration of migratory related protein marker (Fig 9C). These results confirmed that miR-203 attenuates glioma migration through inactivation of GAS41. This evidence concerns the gene CDH1 and central nervous system cancer.