Results showed a clear up regulation of Bax, Caspase-3 and cytochrome C and down regulation of Bcl2 (Fig 8A). The observed result was further confirmed by performing TUNEL assay and caspase 3 assays which also showed a clear increase of apoptosis (Fig 8B and 8C).These results clearly showed that miR-203 play a imperative role in triggering apoptosis and combating cell growth and proliferation in glioma cell lines. Here, CYCS is linked to central nervous system cancer.