YEATS4 and central nervous system cancer: In contrast, HNGC2 or U87 cells co-transfected with miR-203 mimic and mutant 3’UTR of GAS41 construct (GAS41-mut) did not show any change in luciferase signal as compared to control confirming the connectivity of expression of GAS41 with mir203 expression (Fig 2B & 2C). This clearly delineated that miR-203 specifically binds to the 3’UTR of GAS41 in glioma cells which in turn establishes the association of mRNA—miRNA at post transcriptional level which could lead to suppression of GAS41.