IFNG and Skin rash: Pollack et al investigated potential effects of EGFR inhibition on the expression of MHC-I, MHC-II, and CIITA complex of skin keratinocytes, and found that indeed EGFR inhibition augmented IFNγ induced expression of MHC-I, MHC-II, and CIITA complex, thus suggesting a potential interplay of autoreactive T cells in the mechanism of EGFR induced skin rash [18].