CD274 and lung carcinoma: Further, the analysis of gene expression dataset of 186 lung cancer cell lines from CCLE revealed that the overexpression of PD-L1 is associated with higher expression of EGFR and sensitivity to EGFR inhibitors, higher expression of genes related to MHC-I and MHC-II antigen presenting pathways, inflammation and IFNγ signaling pathway, and chemokines for certain inflammatory immune cells such as neutrophils.