Considering H441 is not the most sensitive cell line to EGFR inhibitor compared to ones with sensitive EGFR mutations (e.g. HCC827 or HCC4006), it is possible to extrapolate our results that EGFR inhibition could facilitate neo-antigen specific T cell responses and subsequent tumor killing in lung cancer especially with sensitive EGFR mutations. This evidence concerns the gene EGFR and neoplasm.