PD-L1high lung cancer cell lines showed a greater expression of selected genes involved in class I antigen presenting pathway (HLA-A, Calr, TAP1&2, PSMB9, PSMB8, TAPBP) and class II antigen presenting pathway (HLA-DR, LAMP2, HLA-DM, HLA-DO, and CD74) (Fig 6D and 6E), and inflammation such as IL-6 and STAT3, and several positive regulators of transcription factors involved in IFNγ signaling pathway (STAT1, IRF9) (Fig 6F) compared to PD-L1low lung cancer cell lines. Here, IRF9 is linked to lung cancer.