Recently, Liu, et al[15] has conducted a series of tasks, including comparing expressions of miR-132 between HCC and adjacent non-cancerous liver tissue, as well as in several cell lines, exploring cellular functions of miR-132 in HCC via multiple assays, confirming tumor suppressive role of miR-132 in HCC with nude mouse model and establishing PIK3R3 as a new target gene of miR-132. This evidence concerns the gene PIK3R3 and hepatocellular carcinoma.