Indeed, energy metabolism disorders are an important aspect of NASH, as indicated by the fact that insulin resistance promotes the production of arachidonic acid (FADS2)28 and TG (DGAT2)29 and affects mitochondrial fatty acid beta-oxidation by acetyl-CoA acyltransferase 2 (ACAA2)30, which is the target of XLOC_023704 in early NASH minipigs, and the target gene and lncRNA both upregulated. This evidence concerns the gene ACAA2 and Insulin resistance.