SCN1A and Dravet syndrome: 2009b; Carvill et al. 2014; Nava et al. 2014). Additionally, aside from these “missed” coding mutations, we can expect that mutations in noncoding regulatory regions of SCN1A and possibly also epigenetic factors affecting the gene might play a role in the pathogenesis of DS. A negative SCN1A screening should therefore not be considered as an exclusion factor for DS.