In present study, we did not use VEGF and BDNF siRNA expression vectors or blockage of their receptors to test whether the effects of angiogenesis and neurogenesis were suppressed, but based on previous researches on the actions of VEGF and BDNF post-stroke [28, 31–35), we concluded that the therapeutic effect of SF and BP combined with BMSC on angiogenesis and neurogenesis might relate to the enhancement of VEGF and BDNF expressions in IBZ. This evidence concerns the gene BDNF and stroke disorder.