The clock and clock related genes (BMAL, CLOCK, PER1, PER2, PER3, CRY1, CRY2, CSNK1A1, CSNK1E) tended to be either up-regulated or down-regulated from 2-fold to 5-fold in tumour samples compared with matched benign samples. The gene discussed is CRY1; the disease is neoplasm.