EZH2 and osteoporosis: Interestingly, we found that most of the enriched epigenomic elements for osteoporosis are repressed or inactive marks, such as “poised promoter”, “repressed” chromatin regions, EZH2, and repressive H3K27me3 mark, which suggests that osteoporosis-associated genes tend to be affected by repressive or inactive epigenomic marks, and disruption of these transcriptionally inactive or repressive state might be a factor in the disease.