In dormant DA1-3b acute myeloid leukaemia cells17, 18, AKT is down-regulated by glucocorticoid-induced leucine zipper (GILZ), an essential mediator of glucocorticoid activity19, 20, 21 encoded by Tsc22d3 gene that is responsible for the regulation of FOXO3A, resistance to anticancer drugs18, and pro-apoptotic functions18, 20, 21. This evidence concerns the gene TSC22D3 and acute myeloid leukemia.