Additional evidence supporting this conclusion was provided by the proof-of-concept experimental data obtained using a human melanoma dormancy model (Supplementary Fig. S1), which demonstrated that the immune system of our “humanised” mouse model30 inhibited the growth of a primary human melanoma tumour but was unable to eliminate human MeSCs, which were identified according to their H2B-GFP label-retaining properties31, 32 and which disseminated to multiple organs (Supplementary Table S3). Here, H2BC21 is linked to neoplasm.