The exact role of sirtuins in cancer remains controversial with dichotomous functions being reported, for example multiple studies have shown that SIRT1, SIRT3 and SIRT5 can act as tumor promoters or tumor suppressors under different cellular conditions, tumor stage and tissue of origin [11, 32, 43, 52, 61, 63, 65, 66, 113, 119]. Here, SIRT5 is linked to neoplasm.