In the FACS analyses, we found that CD4+ T cells in the peripheral blood and mesenteric lymph nodes were significantly activated in the mice with STZ-induced hyperglycemia compared to the control mice, although there was no difference in the overall size of population and the absolute number of immune cells between the groups (Fig. 1c,d and Supplementary Fig. 2a–d). Here, CD4 is linked to Hyperglycemia.