ERBB2 and breast carcinoma: However, the protection conferred by DDIT3/CHOP knockdown is not complete as there is a significant difference between the palmitate-treated DDIT3/CHOP -knockdown cells and vehicle-treated cells, indicating that other factors besides DDIT3/CHOP might contribute to the toxic effects of exogenous palmitate in HER2/neu-positive SKBR3 breast cancer cells.