BRCA1 and ovarian carcinoma: The BRCA2 peak spanned positions 16847520 to 16915021, which are up to 44 kb upstream of BNC2 and more than 200kb upstream of CNTLN. The increased number of variants in this case is most likely due to reduced statistical power, as the number of BRCA2 mutation carriers diagnosed with ovarian cancer was only one quarter of the number of affected BRCA1 carriers.