FOXC1 and congenital glaucoma: Previously, it has been reported that mice with heterozygous (Foxc1-/+) and homozygous loss of Foxc1 (Foxc1-/-) have anterior segment abnormalities similar to those reported in humans with ASD and congenital glaucoma, such as iris hypoplasia, small or absence of Schlemm’s canal, severely eccentric pupils, displaced Schwalbe’s line, and aberrantly developed TM [30].