However, pathological cytokine responses including IFNγ, IL-6, IL-10, TNFα, and IP-10 [59], all of which are elevated in AB6 mice during fatal Ang71 infection, have been implicated in inducing vascular permeability with the onset of hemorrhagic fever after infection with the related Dengue virus (DENV). This evidence concerns the gene TNF and hemorrhagic fever.